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1.1 鏈夋楂樺垎瀛愮诞鍑濆姂绋鍜屾€ц唱(zh矛)
鏈夋楂樺垎瀛愮诞鍑濆姂鏈夊ぉ鐒堕珮鍒嗗瓙鍜屽悎鎴愰珮鍒嗗瓙鍏╁ぇ椤�銆傚緸鍖栧(xu茅)绲�(ji茅)妲�(g貌u)涓婂彲浠ュ垎鐐轰互涓�3绋鍨嬶細(1)鑱氳兒鍨�-浣庡垎瀛愰噺闄介洟瀛愬瀷闆昏В璩�(zh矛)锛�(2)瀛ｉ姩鍨�-鍒嗗瓙閲忚畩鍖栬寖鍦嶅ぇ锛屽苟鍏锋湁杓冮珮鐨勯櫧闆㈠瓙鎬�锛�(3)涓欑儻閰拌兒鐨勫叡鑱氱墿-鍒嗗瓙閲忚純楂橈紝鍙互骞惧崄钀埌骞剧櫨钀�銆佸咕鍗冭惉锛屽潎浠ヤ钩鐙€鎴栫矇鐙€鐨勫姂鍨嬪嚭鍞�锛屼娇鐢ㄤ笂杓冧笉鏂逛究锛屼絾绲嚌鎬ц兘濂�銆傛牴鎿�(j霉)鍚湁涓嶅悓鐨勫畼鑳藉湗(tu谩n)闆㈣В鍚庣矑瀛愮殑甯堕浕鎯呮硜鍙互鍒嗙偤闄介洟瀛愬瀷銆侀櫚闆㈠瓙鍨嬨€侀潪闆㈠瓙鍨�3澶ч銆傛湁姗熼珮鍒嗗瓙绲嚌鍔戝ぇ鍒嗗瓙涓彲浠ュ付-COO-銆�-NH-銆�-SO3銆�-OH绛夎Κ姘村熀鍦�(tu谩n)锛屽叿鏈夐張鐙€銆佺挵(hu谩n)鐙€绛夊绋祼(ji茅)妲�(g貌u)銆傚洜鍏舵椿鎬у熀鍦�(tu谩n)澶氾紝鍒嗗瓙閲忛珮锛屽叿鏈夌敤閲忓皯锛屾诞娓ｇ敘(ch菐n)閲忓皯锛岀诞鍑濊兘鍔涘挤锛岀诞楂斿鏄撳垎闆�锛岄櫎娌瑰強闄ゆ嚫娴墿鏁堟灉濂界瓑鐗归粸锛屽湪铏曠悊鐓夋补寤㈡按锛屽叾瀹冨伐妤�(y猫)寤㈡按锛岄珮鎳告诞鐗╁虎姘村強鍥烘恫鍒嗛洟涓櫧闆㈠瓙鍨嬬诞鍑濆姂鏈夎憲寤ｆ硾鐨勭敤閫�銆傜壒鍒ユ槸涓欑儻閰拌兒绯诲垪鏈夋楂樺垎瀛愮诞鍑濆姂浠ュ叾鍒嗗瓙閲忛珮锛岀诞鍑濇灦姗嬭兘鍔涘挤鑰岄’绀哄嚭鍦ㄦ按铏曠悊涓殑鍎�(y艒u)瓒婃€�銆�
1.2 闈為洟瀛愬瀷鏈夋楂樺垎瀛愮诞鍑濆姂鑱氫笝鐑叞鑳�
闈為洟瀛愬瀷鏈夋楂樺垎瀛愮诞鍑濆姂涓昏鏄仛涓欑儻閰拌兒銆傚畠鐢变笝鐑叞鑳鸿仛鍚堣€屽緱銆�
1.3 闄伴洟瀛愬瀷鏈夋楂樺垎瀛愮诞鍑濆姂
(1)闄伴洟瀛愬瀷鏈夋楂樺垎瀛愮诞鍑濆姂涓昏鏈夎仛涓欑儻閰�銆佽仛涓欑儻閰搁垑銆佽仛涓欑儻閰搁垼浠ュ強鑱氫笝鐑叞鑳虹殑鍔犲牽姘磋В鐗╃瓑鑱氬悎鐗�銆�
(2)涓欑儻閰拌兒鍜岃嫰涔欑儻纾洪吀楣�銆佹湪璩�(zh矛)纾洪吀楣�銆佷笝鐑吀銆佺敳鍩轰笝鐑吀绛夊叡鑱氱墿銆�
1.4 闄介洟瀛愬瀷鏈夋楂樺垎瀛愮诞鍑濆姂 鑱氫笝鐑叞鑳�
1.4.1 瀛ｉ姩鍖栫殑鑱氫笝鐑叞鑳�
瀛ｉ姩鍖栫殑鑱氫笝鐑叞鑳洪櫧闆㈠瓙鍧囨槸灏�-NH2缍�(j墨ng)閬庣茎鐢插熀鍖栧拰瀛ｉ姩鍖栬€屽緱锛屽彲浠ュ垎鐐鸿仛涓欑儻閰拌兒闄介洟瀛愬寲鍜岄櫧闆㈠瓙鍖栦笝鐑叞鑳鸿仛鍚堛€�
(1)鐢辫仛涓欑儻閰拌兒瀛ｉ姩鍖�
鑱氫笝鐑叞鑳�(PAM)鍏堣垏鐢查啗姘存憾娑插弽鎳�(y墨ng)锛岄叞鑳哄熀閮ㄥ垎缇ョ敳鍩哄寲锛屽叾娆¤垏浠茶兒鍙嶆噳(y墨ng)閫�(j矛n)琛岀兎鑳哄熀鍖�锛岀劧鍚庤垏楣介吀鎴栬兒鍩哄寲瑭﹀姂鍙嶆噳(y墨ng)浣垮彅鑳哄閵ㄥ寲銆�
(2)鐢卞閵ㄥ寲鐨勪笝鐑叞鑳鸿仛鍚�
鍦ㄥ牽鎬ф浠朵笅锛屽厛鐢变笝鐑叞鑳鸿垏鐢查啗姘存憾娑插弽鎳�(y墨ng)锛岀劧鍚庤垏浜岀敳鑳哄弽鎳�(y墨ng)锛屽喎鍗诲悗鍔犻菇閰稿閵ㄥ寲銆傜敘(ch菐n)鐗╃稉(j墨ng)钂哥櫦(f膩)婵冪府銆侀亷婵撅紝寰楀閵ㄥ寲涓欑儻閰拌兒鍠珨銆�
2.4.2 鑱氫笝鐑叞鑳虹殑闄介洟瀛愯鐢熺墿
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2.5 鍏╂€ц仛涓欑儻閰拌兒鑱氬悎鐗�
浠ラ儴鍒嗘按瑙ｈ仛涓欑儻閰拌兒鍔犲叆閬╅噺鐢查啗鍜屼簩鐢茶兒锛岄€氶亷鏇煎凹鑼插弽鎳�(y墨ng)鍚堟垚鍑哄叿鏈夌晶鍩哄拰鑳虹敳鍩虹殑鍏╂€у瀷鑱氫笝鐑叞鑳虹诞鍑濆姂銆�
2.6 涓欑儻閰拌兒鎺ユ灊鍏辫仛鐗�
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